Calculate the value of confidence limit

Calculates confidence limit values for prepared provided, based on chosen parameters.

Usage

calculate_confidence_limit_values(
  diff_uptake_dat,
  confidence_level = 0.98,
  theoretical = FALSE,
  fractional = TRUE,
  n_rep = NULL
)

Arguments

diff_uptake_dat

processed data from DynamX file - using prepare_dataset

confidence_level

confidence level for the test, from range [0, 1]

theoretical

logical, determines if values are theoretical

fractional

logical, determines if values are fractional

n_rep

...

Value

range of confidence limit interval

Details

Function calculate_confidence_limit_values calculates confidence limit using Houde test. The confidence limits are calculated on whole provided dataset. If the user wishes to calculate confidence limit for one, two or more time points, the provided data should be adjusted accordingly.

References

Houde, D., Berkowitz, S.A., and Engen, J.R. (2011). The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies. J Pharm Sci 100, 2071–2086.

See also

read_hdx calculate_diff_uptake create_diff_uptake_dataset

Examples

diff_uptake_dat <- calculate_diff_uptake(alpha_dat)
calculate_confidence_limit_values(diff_uptake_dat)
#> [1] -0.9335823  0.9335823