HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data
Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a staple technology in structural proteomics. HaDeX provides a analytic workflow for HDX-MS data available both as web server or R package, accompanied by dedicated application HaDeXGUI. This is a second version on previously published HaDeX.
Local instance of HaDeX package
You can install the latest development version of the package:
devtools::install_github("hadexversum/HaDeX2")After installation GUI can be accessed locally:
To run the GUI, the dedicated package HaDeXGUI is needed. If is not installed, the called function will check and install it after the confirmation from the user.
Online manual
The HaDeX documentation is available online.
Funding
This work is supported by Foundation of Polish Science (TEAM TECH CORE FACILITY/2016-2/2 Mass Spectrometry of Biopharmaceuticals - improved methodologies for qualitative, quantitative and structural characterization of drugs, proteinaceous drug targets and diagnostic molecules), Narodowe Centrum Nauki (Preludium Bis 1 2019/35/O/NZ2/03745 Wysokorozdzielcza analiza danych z eksperymentów wymiany proton-deuter monitorowanych spektrometrią mas) as well as (Sonata 19 2023/51/D/NZ7/02847 Ujarzmić agregację z AmyloGraphem 2.0: baza danych i model predykcyjny modulatorów samoorganizacji amyloidowej), and Narodowa Agencja Wymiany Akademickiej (PPN/STA/2021/1/00025).