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HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data

Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a staple technology in structural proteomics. HaDeX provides a analytic workflow for HDX-MS data available both as web server (https://hadex2.mslab-ibb.pl/) or R package.

Local instance of HaDeX package

You can install the latest development version of the package:

devtools::install_github("hadexversum/HaDeX2")

After installation GUI can be accessed locally:

To run the GUI, the dedicated package HaDeXGUI is needed. If is not installed, the called function will check and install it after the confirmation from the user.

Online manual

The HaDeX documentation is available online.

Citation

Puchala W, Burdukiewicz M, Kistowski M, Dabrowska KA, Badaczewska-Dawid AE, Cysewski D and Dadlez M (2020). HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data. Bioinformatics, 10.1093/bioinformatics/btaa587.

Funding

This work is supported by Foundation of Polish Science (TEAM TECH CORE FACILITY/2016-2/2 Mass Spectrometry of Biopharmaceuticals - improved methodologies for qualitative, quantitative and structural characterization of drugs, proteinaceous drug targets and diagnostic molecules) and Narodowe Centrum Nauki (Preludium Bis 1 2019/35/O/NZ2/03745 Wysokorozdzielcza analiza danych z eksperymentów wymiany proton-deuter monitorowanych spektrometrią mas).