HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data

Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a staple technology in structural proteomics. HaDeX provides a analytic workflow for HDX-MS data available both as web server (https://hadex2.mslab-ibb.pl/) or R package.

Local instance of HaDeX package

You can install the latest development version of the package:

devtools::install_github("hadexversum/HaDeX2")

After installation GUI can be accessed locally:

library(HaDeX)
HaDeX_gui()

Online manual

The HaDeX documentation is available online.

Citation

Puchala W, Burdukiewicz M, Kistowski M, Dabrowska KA, Badaczewska-Dawid AE, Cysewski D and Dadlez M (2020). HaDeX: Analysis and Visualisation of Hydrogen/Deuterium Exchange Mass Spectrometry Data. Bioinformatics, 10.1093/bioinformatics/btaa587.

Funding

This work is supported by Foundation of Polish Science (TEAM TECH CORE FACILITY/2016-2/2 Mass Spectrometry of Biopharmaceuticals - improved methodologies for qualitative, quantitative and structural characterization of drugs, proteinaceous drug targets and diagnostic molecules) and Narodowe Centrum Nauki (Preludium Bis 1 2019/35/O/NZ2/03745 Wysokorozdzielcza analiza danych z eksperymentów wymiany proton-deuter monitorowanych spektrometrią mas).